Prof. Dr. Alexander Poletaev

 

Causes of “classical” child autism: Do we have a possibility to prevent it?

Abstract

It is proposed that “classic” autism does not apply to genetic diseases, i.e. its appearance is not associated with peculiar genetic aberrations. The direct cause of autism, it seems, is a persistent non-inherited change in the maternal organism that is induced by harmful, basically chemical factors of the environment. In particular, it is caused by changes in the activity of some clones of lymphocytes with well-defined specificity. These alterations will unlikely cause noticeable symptoms in a healthy mature woman, but could negatively affect the development of her immature foetus and be a cause of the abnormal development of the nervous system, digestive system and  affect other systems of the future child. The aforementioned environmentally induced alterations in the immune system are accompanied by persistent, abnormal maternal IgG auto-antibodies, which could be used as an identifier in risk stratification to give birth to a child with autism. In addition, trans-placental transfer of maternal IgG auto antibodies can be an additional factor affecting the development of the foetus. It is important to note that the changes described above are epigenetic and often occurring in the body of a woman long before pregnancy. Most changes can relatively easily be identified and eliminated before planned pregnancy. As a result woman of a risk-group can give birth to a healthy child. The last is directly supported by our observations.

Keywords
Autism – Environment – Woman health – Foetal development – Deviations

Professional Profile
Mecial Doctor, Professor, Immunologist

Previous work
More 200 publications, including:
Poletaev A.B., Shenderov B.A. Autism: Genetics or Epigenetics? ARC Journals of Immunology and Vaccines, 2016, 1, 2, 1-7. Poletaev A., et al. Adaptive maternal immune deviations as a ground for autism spectrum disorders development in the child. Folia Medica 2014; 56(2):73-80. Co-chairman at 6 International autistic conferences

 

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