Alina Poletaeva

Normalization of microbiome leads to a significant improvement of social-communicative behaviour of autistic children

Abstract

The human body from birth to death is a community of multiple viruses and bacteria. The body of an adult is a unique superorganism, containing up to 100 trillion bacteria, which is many times larger than the number of its own cells. Our common metagenome consists of  2 million genes (including a mere 25 thousand human genes). The most abundant symbiotic bacteria are in the large intestine, which producing more than 60% of essential organic substances (i.e. vitamins, growth factors, hormones, neurotransmitters). The symbiotic bacteria form biofilms which prevent intensive growth of pathogenic bacteria. Incorrect antibiotic therapy, prolonged use of some psychotropics and antihistamine drugs often lead to death of symbiotics, allowing pathogenic microbes (such as Clostridium, Klebsiella, etc.) to multiply excessively. Pathogens produce a variety of harmful factors which may disturb functions of the immune system, have general toxic effects, or influence the neural functioning. More than half of our microbiome is anaerobic, which die a few minutes after contact with atmospheric oxygen. These bacteria are very difficult or impossible to detect with the habitual laboratory cultivation of faeces on a nutrient medium. Much more reliable is the method of gas chromatography – mass-spectrometry of the blood samples for measurement the content of molecules-markers specific for the bacterial wall of our aerobic and anaerobic co-habitants. Prominent disturbances of microbiome,  which are often detected in autistic children, require correction. The latter includes measures for the suppression of pathogens (by using bacteriophages or anti-bacterial drugs) combined with the restoration of normal microbiome (with the help of pre-, pro- and metabiotica). Successful normalization of microbiome usually leads to a significant improvement of social-communicative behaviour of autistic children, as well as their general and neurological health state